Research on Current Topics in Alzheimer’s Disease and Its Related Dementias (R01 Clinical Trial Optional)

NIMHD supports research on current topics in Alzheimer’s disease (AD) and its related dementias. AD is a progressive, degenerative disorder of the brain and is the most common form of dementia of older adult populations. It is the sixth leading cause of death in the United States. Prominent behavioral manifestations of AD include impaired memory and mental decline. At least 5 million Americans age 65 and older suffer from AD, and this number is projected to increase. AD is becoming a national health crisis affecting Americans across all regions of the country, indicating the need for research in this health area.

NIMHD priority areas of research include, but are not limited to:

How multiple health determinants (e.g., social, environmental, economic) contribute to AD risk, incidence, age of onset, morbidity and mortality in populations that experience health disparities
How geographic and neighborhood-level factors contribute to AD-related risk, resilience, and health outcomes
The role of access to and quality of care related to AD risk assessment, diagnosis, and treatment in AD-related health disparities
Trajectories of AD-related risk and resilience across the life course in the context of the NIMHD Research Framework

See NOT-MD-19-016 for more details.

Other high-priority topics of interest include the following, which are summarized in the corresponding notices: