Division of Clinical and Health Services Research
Under this research interest area, NIMHD supports a comprehensive range of clinical research and health services research to generate new knowledge to improve health/clinical outcomes and quality of health care for populations that experience health and health care disparities.
The scientific portfolio includes extramural grants, cooperative agreements, and training awards related to the areas described below.
Toward alignment with NIMHD’s goals and priorities, we strongly encourage prospective grantees to contact extramural program officials before submitting applications whether in response to topic-based or parent grant funding announcements.
Clinical Research and Treatment Interventions Within Healthcare Settings
Research to study the health characteristics and clinical manifestations of health conditions among populations that experience health disparities. Furthermore, this type of research pursues the identification of the most effective methods to screen, diagnose, treat, and/or manage health conditions, especially those associated with the highest burden of morbidity and mortality, among populations that experience health disparities. The ultimate goal is to improve health/clinical outcomes and reduce health disparities within the health care context.
Population-Focused Clinical Research Within the Context of Health Care
Research to understand the health characteristics and the various population-specific clinical presentations and/or manifestations of health conditions and their complications, as well as their similarities and differences compared to other populations. Research examples include but are not limited to:
- Identifying appropriate screening or diagnostic criteria to determine disease risk based on clinical presentation of health conditions and their complications and other factors.
- Delineating tailored screening, diagnosis, and disease management methods or biomarkers based on the clinical presentation of health conditions and their complications across the life course.
- Evaluating screening and diagnostic thresholds and treatment response.
Program Contact: Dr. Carolina Solís Sanabria
Health Disparities Within the Context of Health Care Settings
Research to understand and address etiologies of health disparities within the context of clinical care and health services. Research examples include but are not limited to studies that:
- Assess the effectiveness and implementation of evidence-based guidelines for screening, diagnosis, and clinical care for health conditions with high prevalence or burden by age, sex, and gender along the life course, and for persons with multiple coexisting chronic conditions (including rural health care settings).
- Assess access and quality of care (including continuity of care), the timeliness and effectiveness of referral to specialty care, and/or the timeliness and effectiveness of emergency medical care response and the resulting health outcomes in low-income or low-resource settings.
- Study the reduction of preventable visits to the emergency department, hospitalizations, and in-hospital complications and/or mortality.
- Study the relationship between social determinants of health and clinical outcomes.
- Develop new or evaluate existing strategies to integrate genetics and/or genomics or social care into clinical practice.
- Study patient safety and adverse events.
Program Contact: Dr. Dolly Penn White
Preventive and Health Promotion Interventions in Health Care Settings
Research to develop and evaluate preventive or health promotion interventions (e.g., health communication, health education, or wellness programs) designed to:
- Maintain good health.
- Reduce the severity of health conditions.
- Reduce the progression of health conditions.
Research examples include but are not limited to studies that:
- Develop and evaluate interventions to improve timely screening and immunizations and/or vaccinations.
- Develop and evaluate health systems and policy changes that encourage, make available, and enable patients and their families to use information and/or health services.
Program Contact: Dr. Sundania Wonnum
Implementation and Dissemination Research in Health Care Settings
Research to:
- To understand barriers and facilitators to the adoption of and/or adherence to evidence-based practices, interventions, and policies within clinical system processes.
- To develop and evaluate strategies to enhance successful adoption, adherence, feasibility, and sustainability of evidence-based practices, interventions, and policies.
Research should incorporate elements of scalability and sustainability, particularly in low-resource clinical and community settings.
Research examples include but are not limited to studies that:
- Develop and evaluate strategies to improve adherence to evidence-based screening guidelines in low-resource clinical and community settings.
- Develop and evaluate the implementation of artificial intelligence algorithms, predicting the success of medical care within home-based settings, such as palliative or hospital-at-home.
- Develop and evaluate strategies to implement de-prescribing strategies within long-term care settings.
Program Contact: Dr. Lynne Padgett
Patient-Clinician-Health Care System Interactions
Research to understand how patient-clinician- health care system interactions affect clinical outcomes and health and health care disparities. Objectives are to:
- Understand patient-clinician, clinician-clinician, clinician-health care system and/or patient-health care system engagement, partnership, trust, communication, and shared decision-making.
- Understand patient-clinician communication and/or the patient-clinician relationship.
- Develop, test and evaluate interventions that enhance patient-clinician-health care system interactions and their impact on health/clinical outcomes and the reduction of health and health care disparities.
Clinician and/or Health Care System Bias and Cultural Competence
Research focused on:
- Assessing and understanding conscious and unconscious biases and cultural competency of health care providers and other actors within the health care system regarding patients from populations that experience health and health care disparities.
- Assessing and understanding patients’ conscious and unconscious biases regarding health care providers.
- Interventions to reduce those biases and improve cultural competence.
Studies may also assess the impact of those interventions on the quality of care, patients’ health/clinical outcomes, and reduction of health and health care disparities.
Program Contact: Dr. Sundania Wonnum
Patient-Clinician/Health Care System Communication
Research to:
- Understand the nature and patterns of communication between patients and points of contact (clinical and non-clinical) at different levels within the health care system.
- Develop interventions to facilitate effective bidirectional communication, build trust, and mutual respect between patient and clinician, and shared decision-making between health care systems and patients and their families.
- Evaluate the effect of interventions on quality of care and health/clinical outcomes, and on reducing health and health care disparities.
Research examples include but are not limited to studies that:
- Evaluate effective integration of patient communication preferences in clinical encounters.
- Assess how patients’ preferences for shared decision-making impacts communication with clinicians.
- Delineate pathways of communication for patients with disabilities that interfere with typical spoken communication.
Program Contact: Dr. Yewande Oladeinde
Patient Engagement and/or Partnership in Care
Research within clinical settings or in the community offered in conjunction with clinical care to:
- Understand factors in clinical care that facilitate or challenge patient agency, engagement, and/or partnership across the continuum of care.
- Develop interventions to enhance agency, engagement, and/or partnership and evaluate the effect of these interventions on clinical outcomes and/or health and health care disparities.
Research examples include but are not limited studies to:
- Develop, test, and evaluate patient self-management interventions.
- Assess the impact of different health information technologies on health education interventions.
- Determine which patients are most likely to benefit from self-management or supported interventions.
Program Contact: Dr. Yewande Oladeinde
Clinician-Clinician/Healthcare Team Interactions and Wellbeing
Research to:
- Understand care team structure and processes that impact care decisions, clinical care processes, equitable access to quality care, and health and health care disparities.
- Develop and evaluate interventions to improve team-based care delivery and interprofessional competencies.
- Develop and evaluate interventions or address challenges to and breakdowns in care coordination, communication, and collaboration.
- Understand and address the needs of the health care workforce, including workforce supply, distribution, competencies, and diversity, as well as clinical burden, burnout, and resilience.
Research examples include but are not limited to studies that:
- Assess care team structure and processes that promote comprehensive care coordination, effective care transitions, and continuity of care.
- Develop and evaluate interventions to address clinician burnout.
- Assess multi-level interventions to address clinician fatigue.
Program Contact: Dr. Carolina Solís Sanabria
Epidemiology of Health Care Utilization and Outcomes
Research to identify patterns of healthcare utilization, quality, and outcomes, as well as to identify social, environmental, and other determinants of health care utilization patterns and health/clinical outcomes and their contributions to health and health care disparities across the life course.
This type of research may include longitudinal studies, natural experiments (resulting from changes in public or health policies, for example), and predictive or simulation modelling. The use of advanced analytics may include data mining, machine learning, and artificial intelligence. Research may include the linkage of existing and emerging data sources that capture and harmonize data from multiple contextual levels, including the patient, clinician, healthcare team, health system, neighborhood, and policy levels, and the establishment of data repositories and data standardization using common data elements such as the PhenX toolkit.
Program Contact: Dr. Rada Dagher
System-Level Health Services Research
Research to understand how health care system factors influence health/clinical outcomes.
Health Care System Organization and Coordination
Research that examines how the structure and organization of health care delivery affects health service access, utilization, and clinical outcomes.
Research examples include but are not limited to studies that:
- Evaluate or design interventions involving different units or levels of health care coordination within a single health care system or across multiple health care systems.
- Assess the components of existing or newly designed health care models.
- Evaluate the effectiveness of various strategies to increase the supply of and access to clinicians in medically underserved areas.
- Develop and test coordination and collaboration tools and/or modalities using health information technology or telemedicine.
Program Contact: Dr. Yewande Oladeinde
Health Care Policies
Research to:
- Examine and evaluate the impact of changes in local, state, and/or federal health care policies on health services access, utilization, quality of care, and clinical outcomes.
- Design health policy interventions that make the health care delivery system more affordable, equitable, and higher quality.
Research examples include but are not limited to studies that:
- Evaluate the impact of a specific health care or public policy on access to care.
- Develop and test policy interventions to improve adoption and implementation of evidence-based clinical recommendations.
Program Contact: Dr. Rada Dagher
Interventions to Improve Quality of Care
Research to develop and/or evaluate interventions (health care system-wide or multi-level with system-level components) to reduce system bias, increase health equity, improve access to care, quality of care, and clinical outcomes.
Research examples include but are not limited to studies that:
- Optimally define and assess the integration of social determinants of health in electronic health records or social care into clinical practice.
- Assess the impact of telemedicine on continuity of care, treatment adherence, and/or clinical outcomes.
- Assess the effects of in-home medical services (including pharmacy) on clinical outcomes.
Program Contact: Dr. Dolly Penn White
Healthcare Delivery in Community-Based Settings
Research to understand health care utilization and outcomes in association with services and treatment provided in community-based settings (outside of traditional health care systems) for populations that experience health and/or health care disparities. Studies that explore community health systems and/or academic partnerships. Studies that seek to understand the medical neighborhood and interactions between health care systems and community-based settings.
Health Care Delivery in Behavioral Health Settings
Research to understand and/or improve formal care for populations that experience health and/or health care disparities in community based mental health, drug treatment, and related settings, including clinics, private practice settings, residential treatment facilities, and detoxification centers.
Program Contact: Dr. Rada Dagher
Health Care Delivery in Long-Term, Palliative, or End-of-Life Care Settings
Research to understand or improve formal health care provided to populations that experience health and/or health care disparities (including underserved rural populations) in nursing homes, rehabilitation centers, assisted-living facilities, hospice settings, long-term care facilities, ambulatory or home-based palliative care, and in home-based long-term health care.
Program Contact: Dr. Lynne Padgett
Health Care Delivery in Non-Healthcare Settings
Research to understand or improve formal health care provided to populations that experience health and/or health care disparities in school-based health centers, the workplace, and criminal justice settings. This does not include health promotion activities that may be delivered by non-medical personnel in those or other settings (for example, health fairs).
Program Contact: Dr. Sundania Wonnum
Page updated July 24, 2024